Cell atlas - CEP89 - The Human Protein Atlas

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CEP89

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CEP89
Gene description	Centrosomal protein 89kDa
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the cytosol. In addition localized to the plasma membrane.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (supported)
Additional location	In addition localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Supported based on 2 antibodies. HPA039382 , HPA040056
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ASSAYS

RNA expression

Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the cytosol. In addition localized to the plasma membrane.

Main location

Cytosol (supported)

Additional location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA039382	A-431	Cytosol
HPA039382	U-251 MG	Cytosol
HPA040056	A-431	Plasma membrane
HPA040056	A-431	Cytosol
HPA040056	U-2 OS	Plasma membrane
HPA040056	U-2 OS	Cytosol
HPA040056	U-251 MG	Plasma membrane
HPA040056	U-251 MG	Cytosol

GENE INFORMATION
Gene name	CEP89 (HGNC Symbol)
Synonyms	CCDC123, FLJ14640
Description	Centrosomal protein 89kDa (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.11
Chromosome location (bp)	32875925 - 32971991
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121289 (version 83.38)
Entrez gene	84902
UniProt	Q96ST8 (UniProt - Evidence at protein level)
neXtProt	NX_Q96ST8
Antibodypedia	CEP89 antibodies

PROTEIN BROWSER

CEP89-001	CEP89-005	CEP89-006	CEP89-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP89-001 ENSP00000306105 ENST00000305768	Q96ST8 [Direct mapping] Centrosomal protein of 89 kDa Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000922 [spindle pole] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005758 [mitochondrial intermembrane space] GO:0005813 [centrosome] GO:0005814 [centriole] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006996 [organelle organization] GO:0031513 [nonmotile primary cilium] GO:0031514 [motile cilium] GO:0035058 [nonmotile primary cilium assembly] GO:0042384 [cilium assembly] GO:0097539 [ciliary transition fiber] Show all	783 aa 89.6 kDa	No	0
CEP89-005 ENSP00000466442 ENST00000590597	A0A0C4DGP8 [Direct mapping] Centrosomal protein of 89 kDa Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		356 aa 40.2 kDa	Yes	0
CEP89-006 ENSP00000467839 ENST00000593276	K7EQI2 [Direct mapping] Centrosomal protein of 89 kDa Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		217 aa 23.9 kDa	Yes	0
CEP89-010 ENSP00000481256 ENST00000591863	A0A087WXS8 [Direct mapping] Centrosomal protein of 89 kDa Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		80 aa 9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.