Expression of HCRTR1 in cancer - Summary

CANCER ATLAS

Gene description

Hypocretin (orexin) receptor 1

Protein class

FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA014018

GENE INFORMATION
Gene name	HCRTR1 (HGNC Symbol)
Synonyms	OX1R
Description	Hypocretin (orexin) receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	31617686 - 31632518
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000121764 (version 83.38)
Entrez gene	3061
UniProt	O43613 (UniProt - Evidence at transcript level)
neXtProt	NX_O43613
Antibodypedia	HCRTR1 antibodies

PROTEIN BROWSER

HCRTR1-001	HCRTR1-002	HCRTR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HCRTR1-001 ENSP00000362810 ENST00000373706	O43613 [Direct mapping] Orexin receptor type 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007631 [feeding behavior] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0016499 [orexin receptor activity] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045187 [regulation of circadian sleep/wake cycle, sleep] GO:1901652 [response to peptide] Show all	425 aa 47.5 kDa	No	7
HCRTR1-002 ENSP00000362809 ENST00000373705	A6NMV7 [Direct mapping] Orexin receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007631 [feeding behavior] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0016499 [orexin receptor activity] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045187 [regulation of circadian sleep/wake cycle, sleep] GO:1901652 [response to peptide] Show all	389 aa 43.6 kDa	No	7
HCRTR1-201 ENSP00000384387 ENST00000403528	O43613 [Direct mapping] Orexin receptor type 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0007631 [feeding behavior] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0016499 [orexin receptor activity] GO:0017046 [peptide hormone binding] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045187 [regulation of circadian sleep/wake cycle, sleep] GO:1901652 [response to peptide] Show all	425 aa 47.5 kDa	No	7