Tissue expression of HCRTR1 - Summary - The Human Protein Atlas

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HCRTR1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	HCRTR1
Gene description	Hypocretin (orexin) receptor 1
Protein class	FDA approved drug targets G-protein coupled receptors Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Tissue enhanced (hypothalamus)
FANTOM5:	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at transcript level

Protein expression

Selective expression in CNS, most abundant in Purkinje cells.

DATA RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA014018
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (hypothalamus)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (thyroid gland)

GENE INFORMATION
Gene name	HCRTR1 (HGNC Symbol)
Synonyms	OX1R
Description	Hypocretin (orexin) receptor 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein selectively binds the hypothalamic neuropeptide orexin A. A related gene (HCRTR2) encodes a G-protein coupled receptor that binds orexin A and orexin B. [provided by RefSeq, Jan 2009]
Chromosome	1
Cytoband	p35.2
Chromosome location (bp)	31617686 - 31632518
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000121764 (version 83.38)
Entrez gene	3061
UniProt	O43613 (UniProt - Evidence at transcript level)
neXtProt	NX_O43613
Antibodypedia	HCRTR1 antibodies

PROTEIN BROWSER

HCRTR1-001	HCRTR1-002	HCRTR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HCRTR1-001 ENSP00000362810 ENST00000373706	O43613 [Direct mapping] Orexin receptor type 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007268 [synaptic transmission] GO:0007631 [feeding behavior] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0016499 [orexin receptor activity] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045187 [regulation of circadian sleep/wake cycle, sleep] GO:1901652 [response to peptide] Show all	425 aa 47.5 kDa	No	7
HCRTR1-002 ENSP00000362809 ENST00000373705	A6NMV7 [Direct mapping] Orexin receptor type 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007631 [feeding behavior] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0016499 [orexin receptor activity] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045187 [regulation of circadian sleep/wake cycle, sleep] GO:1901652 [response to peptide] Show all	389 aa 43.6 kDa	No	7
HCRTR1-201 ENSP00000384387 ENST00000403528	O43613 [Direct mapping] Orexin receptor type 1 Show all	G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007218 [neuropeptide signaling pathway] GO:0007268 [synaptic transmission] GO:0007631 [feeding behavior] GO:0008188 [neuropeptide receptor activity] GO:0016021 [integral component of membrane] GO:0016499 [orexin receptor activity] GO:0017046 [peptide hormone binding] GO:0032870 [cellular response to hormone stimulus] GO:0042277 [peptide binding] GO:0045187 [regulation of circadian sleep/wake cycle, sleep] GO:1901652 [response to peptide] Show all	425 aa 47.5 kDa	No	7

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.