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Rare cases of lobular carcinomas of breast showed weak to moderate cytoplasmic staining. Several cases of colorectal cancers displayed weak to moderate cytoplasmic and membranous positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
FABP3 (HGNC Symbol)
Synonyms
FABP11, H-FABP, MDGI, O-FABP
Description
Fatty acid binding protein 3, muscle and heart (HGNC Symbol)
Entrez gene summary
The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]
Predicted intracellular proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
