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FABP3

GENERAL INFORMATION

Gene name

 FABP3

Gene description

 Fatty acid binding protein 3, muscle and heart

Protein class

 Candidate cardiovascular disease genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (heart muscle)
GTEx:Group enriched (heart muscle, skeletal muscle)
FANTOM5:Group enriched (heart muscle, skeletal muscle)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression mainly in heart muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA055754 , CAB017830
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (heart muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (heart muscle, skeletal muscle)

GENE INFORMATION

Gene name

 FABP3 (HGNC Symbol)

Synonyms

 FABP11, H-FABP, MDGI, O-FABP

Description

 Fatty acid binding protein 3, muscle and heart (HGNC Symbol)

Entrez gene summary

 The intracellular fatty acid-binding proteins (FABPs) belongs to a multigene family. FABPs are divided into at least three distinct types, namely the hepatic-, intestinal- and cardiac-type. They form 14-15 kDa proteins and are thought to participate in the uptake, intracellular metabolism and/or transport of long-chain fatty acids. They may also be responsible in the modulation of cell growth and proliferation. Fatty acid-binding protein 3 gene contains four exons and its function is to arrest growth of mammary epithelial cells. This gene is a candidate tumor suppressor gene for human breast cancer. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.2

Chromosome location (bp)

 31365625 - 31376850

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121769 (version 83.38)

Entrez gene

 2170

UniProt

 P05413 (UniProt - Evidence at protein level)

neXtProt

 NX_P05413

Antibodypedia

 FABP3 antibodies

PROTEIN BROWSER
FABP3-001
FABP3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FABP3-001
ENSP00000362817
ENST00000373713
P05413 [Direct mapping]
Fatty acid-binding protein, heart
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Predicted intracellular proteins
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0005324 [long-chain fatty acid transporter activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006631 [fatty acid metabolic process]
GO:0006810 [transport]
GO:0007507 [heart development]
GO:0008092 [cytoskeletal protein binding]
GO:0008285 [negative regulation of cell proliferation]
GO:0008289 [lipid binding]
GO:0015909 [long-chain fatty acid transport]
GO:0016528 [sarcoplasm]
GO:0019433 [triglyceride catabolic process]
GO:0032868 [response to insulin]
GO:0035727 [lysophosphatidic acid binding]
GO:0036041 [long-chain fatty acid binding]
GO:0042493 [response to drug]
GO:0042632 [cholesterol homeostasis]
GO:0044281 [small molecule metabolic process]
GO:0044539 [long-chain fatty acid import]
GO:0046320 [regulation of fatty acid oxidation]
GO:0050543 [icosatetraenoic acid binding]
GO:0055091 [phospholipid homeostasis]
GO:0070062 [extracellular exosome]
GO:0070538 [oleic acid binding]
GO:0070542 [response to fatty acid]
GO:0071073 [positive regulation of phospholipid biosynthetic process]
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 133 aa
14.9 kDa 		No 0
FABP3-003
ENSP00000473982
ENST00000482018
S4R371 [Direct mapping]
Fatty acid-binding protein, heart
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0007507 [heart development]
GO:0008289 [lipid binding]
GO:0035727 [lysophosphatidic acid binding]
Show all
 132 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.