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PDS5A

GENERAL INFORMATION

Gene name

 PDS5A

Gene description

 PDS5 cohesin associated factor A

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. Pending external verification.

Reliability score

 Supported based on 2 antibodies.
HPA036661 , HPA036662
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PDS5A (HGNC Symbol)

Synonyms

 KIAA0648, PIG54, SCC-112

Description

 PDS5 cohesin associated factor A (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Chromosome

 4

Cytoband

 p14

Chromosome location (bp)

 39822863 - 39977956

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000121892 (version 83.38)

Entrez gene

 23244

UniProt

 Q29RF7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q29RF7

Antibodypedia

 PDS5A antibodies

PROTEIN BROWSER
PDS5A-001
PDS5A-003
PDS5A-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PDS5A-001
ENSP00000303427
ENST00000303538
Q29RF7 [Direct mapping]
Sister chromatid cohesion protein PDS5 homolog A
G1UI16 [Target identity:100%; Query identity:100%]
SCC-112 protein, isoform CRA_b; Sister chromatid cohesion protein PDS5 homolog A
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   MEMSAT3 predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000785 [chromatin]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007064 [mitotic sister chromatid cohesion]
GO:0008156 [negative regulation of DNA replication]
GO:0051301 [cell division]
Show all
 1337 aa
150.8 kDa 		No 0
PDS5A-003
ENSP00000426749
ENST00000503396
Q29RF7 [Direct mapping]
Sister chromatid cohesion protein PDS5 homolog A
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000278 [mitotic cell cycle]
GO:0000775 [chromosome, centromeric region]
GO:0000785 [chromatin]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005694 [chromosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007064 [mitotic sister chromatid cohesion]
GO:0008156 [negative regulation of DNA replication]
GO:0051301 [cell division]
Show all
 600 aa
69 kDa 		No 0
PDS5A-006
ENSP00000424531
ENST00000513798
H0Y9L9 [Direct mapping]
Sister chromatid cohesion protein PDS5 homolog A
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 165 aa
19.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.