Expression of LIAS in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Lipoic acid synthetase

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA018842	HPA019076

GENE INFORMATION
Gene name	LIAS (HGNC Symbol)
Synonyms	LAS
Description	Lipoic acid synthetase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the biotin and lipoic acid synthetases family. It localizes in mitochondrion and plays an important role in alpha-(+)-lipoic acid synthesis. It may also function in the sulfur insertion chemistry in lipoate biosynthesis. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]
Chromosome	4
Cytoband	p14
Chromosome location (bp)	39459000 - 39477653
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000121897 (version 83.38)
Entrez gene	11019
UniProt	O43766 (UniProt - Evidence at protein level)
neXtProt	NX_O43766
Antibodypedia	LIAS antibodies

PROTEIN BROWSER

LIAS-001	LIAS-002	LIAS-006	LIAS-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LIAS-001 ENSP00000261434 ENST00000261434	O43766 [Direct mapping] Lipoyl synthase, mitochondrial A0A024R9W0 [Target identity:100%; Query identity:100%] Lipoyl synthase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001843 [neural tube closure] GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0009107 [lipoate biosynthetic process] GO:0009249 [protein lipoylation] GO:0016992 [lipoate synthase activity] GO:0032496 [response to lipopolysaccharide] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	372 aa 41.9 kDa	No	0
LIAS-002 ENSP00000371270 ENST00000381846	O43766 [Direct mapping] Lipoyl synthase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0009107 [lipoate biosynthetic process] GO:0009249 [protein lipoylation] GO:0016992 [lipoate synthase activity] GO:0032496 [response to lipopolysaccharide] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	329 aa 37.1 kDa	No	0
LIAS-006 ENSP00000425580 ENST00000513731	D6RCP8 [Direct mapping] Lipoyl synthase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0009107 [lipoate biosynthetic process] GO:0016992 [lipoate synthase activity] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	242 aa 27.5 kDa	No	0
LIAS-008 ENSP00000340676 ENST00000340169	O43766 [Direct mapping] Lipoyl synthase, mitochondrial Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003824 [catalytic activity] GO:0005739 [mitochondrion] GO:0006954 [inflammatory response] GO:0006979 [response to oxidative stress] GO:0009107 [lipoate biosynthetic process] GO:0009249 [protein lipoylation] GO:0016992 [lipoate synthase activity] GO:0032496 [response to lipopolysaccharide] GO:0046872 [metal ion binding] GO:0051536 [iron-sulfur cluster binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	322 aa 36.1 kDa	No	0