Expression of FAM126A in cancer - Summary

CANCER ATLAS

Gene description

Family with sequence similarity 126, member A

Protein class

Disease related genes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA042873

GENE INFORMATION
Gene name	FAM126A (HGNC Symbol)
Synonyms	DRCTNNB1A , HCC, HYCC1, hyccin
Description	Family with sequence similarity 126, member A (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may play a part in the beta-catenin/Lef signaling pathway. Expression of this gene is down-regulated by beta-catenin. Defects in this gene are a cause of hypomyelination with congenital cataract (HCC). [provided by RefSeq, Oct 2008]
Chromosome	7
Cytoband	p15.3
Chromosome location (bp)	22889371 - 23014130
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122591 (version 83.38)
Entrez gene	84668
UniProt	Q9BYI3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYI3
Antibodypedia	FAM126A antibodies

PROTEIN BROWSER

FAM126A-001	FAM126A-002	FAM126A-006	FAM126A-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
FAM126A-001 ENSP00000403396 ENST00000432176	Q9BYI3 [Direct mapping] Hyccin A0A024RA06 [Target identity:100%; Query identity:100%] Down-regulated by Ctnnb1, a, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007165 [signal transduction] GO:0008150 [biological_process] Show all	521 aa 57.6 kDa	No	0
FAM126A-002 ENSP00000397168 ENST00000440481	H7C0W7 [Direct mapping] Hyccin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		471 aa 52 kDa	No	0
FAM126A-006 ENSP00000386246 ENST00000409923	B8ZZJ1 [Direct mapping] Hyccin Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		419 aa 46.9 kDa	No	0
FAM126A-008 ENSP00000386624 ENST00000409763	B8ZZA2 [Direct mapping] Hyccin Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 13 kDa	No	0