Expression of RECK in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Reversion-inducing-cysteine-rich protein with kazal motifs

Protein class

Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB025109

GENE INFORMATION
Gene name	RECK (HGNC Symbol)
Synonyms	hRECK, ST15
Description	Reversion-inducing-cysteine-rich protein with kazal motifs (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	36036433 - 36124451
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122707 (version 83.38)
Entrez gene	8434
UniProt	O95980 (UniProt - Evidence at protein level)
neXtProt	NX_O95980
Antibodypedia	RECK antibodies

PROTEIN BROWSER

RECK-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RECK-001 ENSP00000367202 ENST00000377966	O95980 [Direct mapping] Reversion-inducing cysteine-rich protein with Kazal motifs Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001955 [blood vessel maturation] GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007566 [embryo implantation] GO:0008191 [metalloendopeptidase inhibitor activity] GO:0010951 [negative regulation of endopeptidase activity] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0030336 [negative regulation of cell migration] GO:0031225 [anchored component of membrane] GO:0035115 [embryonic forelimb morphogenesis] Show all	971 aa 106.5 kDa	Yes	1