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RECK

GENERAL INFORMATION

Gene name

 RECK

Gene description

 Reversion-inducing-cysteine-rich protein with kazal motifs

Protein class

 Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Distinct positivity in extracellular matrix with additional cytoplasmic expression in several tissues.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
CAB025109
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RECK (HGNC Symbol)

Synonyms

 hRECK, ST15

Description

 Reversion-inducing-cysteine-rich protein with kazal motifs (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 36036433 - 36124451

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122707 (version 83.38)

Entrez gene

 8434

UniProt

 O95980 (UniProt - Evidence at protein level)

neXtProt

 NX_O95980

Antibodypedia

 RECK antibodies

PROTEIN BROWSER
RECK-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RECK-001
ENSP00000367202
ENST00000377966
O95980 [Direct mapping]
Reversion-inducing cysteine-rich protein with Kazal motifs
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001955 [blood vessel maturation]
GO:0004866 [endopeptidase inhibitor activity]
GO:0004867 [serine-type endopeptidase inhibitor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0007566 [embryo implantation]
GO:0008191 [metalloendopeptidase inhibitor activity]
GO:0010951 [negative regulation of endopeptidase activity]
GO:0016020 [membrane]
GO:0030198 [extracellular matrix organization]
GO:0030336 [negative regulation of cell migration]
GO:0031225 [anchored component of membrane]
GO:0035115 [embryonic forelimb morphogenesis]
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 971 aa
106.5 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.