Expression of CNTFR in cancer - Summary

CANCER ATLAS

Gene description

Ciliary neurotrophic factor receptor

Protein class

Plasma proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

CAB025310

GENE INFORMATION
Gene name	CNTFR
Synonyms
Description	Ciliary neurotrophic factor receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]
Chromosome	9
Cytoband	p13.3
Chromosome location (bp)	34551432 - 34590140
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122756 (version 83.38)
Entrez gene	1271
UniProt	P26992 (UniProt - Evidence at protein level)
neXtProt	NX_P26992
Antibodypedia	CNTFR antibodies

PROTEIN BROWSER

CNTFR-001	CNTFR-002	CNTFR-003	CNTFR-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CNTFR-001 ENSP00000368265 ENST00000378980	P26992 [Direct mapping] Ciliary neurotrophic factor receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001967 [suckling behavior] GO:0003360 [brainstem development] GO:0004896 [cytokine receptor activity] GO:0004897 [ciliary neurotrophic factor receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0007548 [sex differentiation] GO:0008284 [positive regulation of cell proliferation] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0019898 [extrinsic component of membrane] GO:0019955 [cytokine binding] GO:0031225 [anchored component of membrane] GO:0043524 [negative regulation of neuron apoptotic process] GO:0060538 [skeletal muscle organ development] GO:0070110 [ciliary neurotrophic factor receptor complex] GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway] GO:0097059 [CNTFR-CLCF1 complex] Show all	372 aa 40.6 kDa	Yes	1
CNTFR-002 ENSP00000242338 ENST00000351266	P26992 [Direct mapping] Ciliary neurotrophic factor receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004897 [ciliary neurotrophic factor receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0019898 [extrinsic component of membrane] GO:0019955 [cytokine binding] GO:0031225 [anchored component of membrane] GO:0070110 [ciliary neurotrophic factor receptor complex] GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway] GO:0097059 [CNTFR-CLCF1 complex] Show all	372 aa 40.6 kDa	Yes	1
CNTFR-003 ENSP00000388082 ENST00000417345	Q5T8H6 [Direct mapping] Ciliary neurotrophic factor receptor subunit alpha Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0016020 [membrane] GO:0019221 [cytokine-mediated signaling pathway] Show all	256 aa 28.8 kDa	Yes	0
CNTFR-201 ENSP00000480451 ENST00000610543	P26992 [Direct mapping] Ciliary neurotrophic factor receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004896 [cytokine receptor activity] GO:0004897 [ciliary neurotrophic factor receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0007399 [nervous system development] GO:0016020 [membrane] GO:0016324 [apical plasma membrane] GO:0019898 [extrinsic component of membrane] GO:0019955 [cytokine binding] GO:0031225 [anchored component of membrane] GO:0070110 [ciliary neurotrophic factor receptor complex] GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway] GO:0097059 [CNTFR-CLCF1 complex] Show all	372 aa 40.6 kDa	Yes	1