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CNTFR

GENERAL INFORMATION

Gene name

 CNTFR

Gene description

 Ciliary neurotrophic factor receptor

Protein class

 Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (adipose tissue, cerebral cortex)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
CAB025310
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

 CNTFR

Synonyms

Description

 Ciliary neurotrophic factor receptor (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Chromosome

 9

Cytoband

 p13.3

Chromosome location (bp)

 34551432 - 34590140

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122756 (version 83.38)

Entrez gene

 1271

UniProt

 P26992 (UniProt - Evidence at protein level)

neXtProt

 NX_P26992

Antibodypedia

 CNTFR antibodies

PROTEIN BROWSER
CNTFR-001
CNTFR-002
CNTFR-003
CNTFR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CNTFR-001
ENSP00000368265
ENST00000378980
P26992 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001967 [suckling behavior]
GO:0003360 [brainstem development]
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007548 [sex differentiation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019955 [cytokine binding]
GO:0031225 [anchored component of membrane]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0060538 [skeletal muscle organ development]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097059 [CNTFR-CLCF1 complex]
Show all
 372 aa
40.6 kDa 		Yes 1
CNTFR-002
ENSP00000242338
ENST00000351266
P26992 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019955 [cytokine binding]
GO:0031225 [anchored component of membrane]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097059 [CNTFR-CLCF1 complex]
Show all
 372 aa
40.6 kDa 		Yes 1
CNTFR-003
ENSP00000388082
ENST00000417345
Q5T8H6 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 256 aa
28.8 kDa 		Yes 0
CNTFR-201
ENSP00000480451
ENST00000610543
P26992 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019955 [cytokine binding]
GO:0031225 [anchored component of membrane]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097059 [CNTFR-CLCF1 complex]
Show all
 372 aa
40.6 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.