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Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CNTFR
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TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation


Dictionary


Tissue proteome

GENERAL INFORMATION

Gene name

CNTFR

Gene description

Ciliary neurotrophic factor receptor

Protein class

Plasma proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Membrane,Secreted

Number of transcripts

4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:Tissue enhanced (adipose tissue, cerebral cortex)
GTEx:Expressed in all
FANTOM5:Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

Antibody staining mainly not consistent with RNA expression data.

Reliability score

Approved based on 1 antibody.
CAB025310
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM) Protein expression (score)
Brain
Cerebral cortex
Hippocampus
N/A
Caudate
N/A
Cerebellum
N/A
Endocrine tissues
Thyroid gland
Parathyroid gland
Adrenal gland
Bone marrow & immune system
Appendix
Bone marrow
Lymph node
Tonsil
Spleen
Muscle tissues
Heart muscle
Skeletal muscle
Smooth muscle
Lung
Nasopharynx
N/A
Bronchus
N/A
Lung
Liver & gallbladder
Liver
Gallbladder
Pancreas
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
Salivary gland
Esophagus
Stomach
Duodenum
Small intestine
Colon
Rectum
Kidney & urinary bladder
Kidney
Urinary bladder
Male tissues
Testis
Epididymis
Prostate
Seminal vesicle
Female tissues
Breast
Vagina
N/A
Cervix, uterine
Endometrium
Fallopian tube
Ovary
Placenta
Adipose & soft tissue
Adipose tissue
Soft tissue
N/A
Skin
Skin
Cerebral cortex

Lymph node

Skeletal muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW

Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW

HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (adipose tissue, cerebral cortex)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION

Gene name

CNTFR

Synonyms

Description

Ciliary neurotrophic factor receptor (HGNC Symbol)

Entrez gene summary

This gene encodes a member of the type 1 cytokine receptor family. The encoded protein is the ligand-specific component of a tripartite receptor for ciliary neurotrophic factor, which plays a critical role in neuronal cell survival, differentiation and gene expression. Binding of ciliary neurotrophic factor to the encoded protein recruits the transmembrane components of the receptor, gp130 and leukemia inhibitory factor receptor, facilitating signal transduction. Single nucleotide polymorphisms in this gene may be associated with variations in muscle strength, as well as early onset of eating disorders. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2011]

Chromosome

9

Cytoband

p13.3

Chromosome location (bp)

34551432 - 34590140

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000122756 (version 83.38)

Entrez gene

1271

UniProt

P26992 (UniProt - Evidence at protein level)

neXtProt

NX_P26992

Antibodypedia

CNTFR antibodies

PROTEIN BROWSER

CNTFR-001
CNTFR-002
CNTFR-003
CNTFR-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CNTFR-001
ENSP00000368265
ENST00000378980
P26992 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001967 [suckling behavior]
GO:0003360 [brainstem development]
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0007548 [sex differentiation]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019955 [cytokine binding]
GO:0031225 [anchored component of membrane]
GO:0043524 [negative regulation of neuron apoptotic process]
GO:0060538 [skeletal muscle organ development]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097059 [CNTFR-CLCF1 complex]
Show all
372 aa
40.6 kDa
Yes 1
CNTFR-002
ENSP00000242338
ENST00000351266
P26992 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019955 [cytokine binding]
GO:0031225 [anchored component of membrane]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097059 [CNTFR-CLCF1 complex]
Show all
372 aa
40.6 kDa
Yes 1
CNTFR-003
ENSP00000388082
ENST00000417345
Q5T8H6 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0005515 [protein binding]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
256 aa
28.8 kDa
Yes 0
CNTFR-201
ENSP00000480451
ENST00000610543
P26992 [Direct mapping]
Ciliary neurotrophic factor receptor subunit alpha
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004896 [cytokine receptor activity]
GO:0004897 [ciliary neurotrophic factor receptor activity]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0007165 [signal transduction]
GO:0007399 [nervous system development]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0019898 [extrinsic component of membrane]
GO:0019955 [cytokine binding]
GO:0031225 [anchored component of membrane]
GO:0070110 [ciliary neurotrophic factor receptor complex]
GO:0070120 [ciliary neurotrophic factor-mediated signaling pathway]
GO:0097059 [CNTFR-CLCF1 complex]
Show all
372 aa
40.6 kDa
Yes 1

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