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Testicular cancers and cases of malignant gliomas displayed moderate to strong nuclear positivity. Many cases of colorectal, breast, testicular, urothelial and stomach cancers were moderately stained with additional cytoplasmic positivity in few tissues. Remaining malignant cells were in general weakly stained or negative.
GENE INFORMATION
Gene name
TRIM24 (HGNC Symbol)
Synonyms
hTIF1, RNF82, TIF1, Tif1a
Description
Tripartite motif containing 24 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0005726 [perichromatin fibrils] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030163 [protein catabolic process] GO:0031647 [regulation of protein stability] GO:0034056 [estrogen response element binding] GO:0042981 [regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0055074 [calcium ion homeostasis] GO:0061630 [ubiquitin protein ligase activity] GO:0070562 [regulation of vitamin D receptor signaling pathway] GO:0070577 [lysine-acetylated histone binding] GO:0071391 [cellular response to estrogen stimulus] GO:1901796 [regulation of signal transduction by p53 class mediator]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)