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The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002039 [p53 binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0004672 [protein kinase activity] GO:0004842 [ubiquitin-protein transferase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005719 [nuclear euchromatin] GO:0005726 [perichromatin fibrils] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006468 [protein phosphorylation] GO:0008270 [zinc ion binding] GO:0008285 [negative regulation of cell proliferation] GO:0010628 [positive regulation of gene expression] GO:0016567 [protein ubiquitination] GO:0016874 [ligase activity] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0030163 [protein catabolic process] GO:0031647 [regulation of protein stability] GO:0034056 [estrogen response element binding] GO:0042981 [regulation of apoptotic process] GO:0043565 [sequence-specific DNA binding] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0046777 [protein autophosphorylation] GO:0055074 [calcium ion homeostasis] GO:0061630 [ubiquitin protein ligase activity] GO:0070562 [regulation of vitamin D receptor signaling pathway] GO:0070577 [lysine-acetylated histone binding] GO:0071391 [cellular response to estrogen stimulus] GO:1901796 [regulation of signal transduction by p53 class mediator]
Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
