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CALD1

GENERAL INFORMATION

Gene name

 CALD1

Gene description

 Caldesmon 1

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (seminal vesicle)
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression most abundant in smooth muscle.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Supported based on 3 antibodies.
HPA008066 , HPA017330 , CAB000006
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Smooth muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (seminal vesicle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CALD1 (HGNC Symbol)

Synonyms

 CDM, H-CAD, L-CAD

Description

 Caldesmon 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 7

Cytoband

 q33

Chromosome location (bp)

 134744252 - 134970728

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122786 (version 83.38)

Entrez gene

 800

UniProt

 Q05682 (UniProt - Evidence at protein level)

neXtProt

 NX_Q05682

Antibodypedia

 CALD1 antibodies

PROTEIN BROWSER
«
CALD1-001
CALD1-002
CALD1-003
CALD1-005
CALD1-010
CALD1-012
CALD1-017
CALD1-020
CALD1-027
CALD1-029
CALD1-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CALD1-001
ENSP00000354513
ENST00000361901
Q05682 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0017022 [myosin binding]
GO:0030016 [myofibril]
Show all
 538 aa
62.7 kDa 		No 0
CALD1-002
ENSP00000398826
ENST00000417172
Q05682 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0017022 [myosin binding]
GO:0030016 [myofibril]
Show all
 538 aa
62.7 kDa 		No 0
CALD1-003
ENSP00000395710
ENST00000422748
Q05682 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0017022 [myosin binding]
GO:0030016 [myofibril]
Show all
 563 aa
65.6 kDa 		No 0
CALD1-005
ENSP00000354826
ENST00000361675
Q05682 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0016020 [membrane]
GO:0017022 [myosin binding]
GO:0030016 [myofibril]
GO:0030478 [actin cap]
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 793 aa
93.2 kDa 		No 0
CALD1-010
ENSP00000393621
ENST00000424922
Q05682 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0017022 [myosin binding]
GO:0030016 [myofibril]
Show all
 532 aa
61.2 kDa 		No 0
CALD1-012
ENSP00000411476
ENST00000436461
C9J813 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0017022 [myosin binding]
Show all
 459 aa
54.2 kDa 		No 0
CALD1-017
ENSP00000401988
ENST00000454108
C9JE79 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0006936 [muscle contraction]
GO:0017022 [myosin binding]
Show all
 72 aa
9 kDa 		No 0
CALD1-020
ENSP00000416611
ENST00000435928
C9JE79 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0006936 [muscle contraction]
GO:0017022 [myosin binding]
Show all
 72 aa
9 kDa 		No 0
CALD1-027
ENSP00000390926
ENST00000445569
C9JEK3 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0006936 [muscle contraction]
GO:0017022 [myosin binding]
Show all
 132 aa
16 kDa 		No 0
CALD1-029
ENSP00000419673
ENST00000495522
E7EX44 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005886 [plasma membrane]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0017022 [myosin binding]
Show all
 557 aa
64.2 kDa 		No 0
CALD1-201
ENSP00000376826
ENST00000393118
Q05682 [Direct mapping]
Caldesmon
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005516 [calmodulin binding]
GO:0005523 [tropomyosin binding]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0006928 [movement of cell or subcellular component]
GO:0006936 [muscle contraction]
GO:0015629 [actin cytoskeleton]
GO:0017022 [myosin binding]
GO:0030016 [myofibril]
Show all
 558 aa
64.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.