Cell atlas - SFTPA1 - The Human Protein Atlas

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SFTPA1

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	SFTPA1
Gene description	Surfactant protein A1
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Group enriched (RPMI-8226, U-2197)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPMI-8226, U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SFTPA1 (HGNC Symbol)
Synonyms	COLEC4, SFTP1, SP-A, SP-A1
Description	Surfactant protein A1 (HGNC Symbol)
Entrez gene summary	This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Chromosome	10
Cytoband	q22.3
Chromosome location (bp)	79610939 - 79615455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122852 (version 83.38)
Entrez gene	653509
UniProt	Q8IWL2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWL2
Antibodypedia	SFTPA1 antibodies

PROTEIN BROWSER

SFTPA1-007	SFTPA1-008	SFTPA1-009	SFTPA1-201	SFTPA1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFTPA1-007 ENSP00000395527 ENST00000429958	A0A0C4DG36 [Direct mapping] Pulmonary surfactant-associated protein A1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		158 aa 16 kDa	Yes	0
SFTPA1-008 ENSP00000397082 ENST00000419470	Q8IWL2 [Direct mapping] Pulmonary surfactant-associated protein A1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	263 aa 27.7 kDa	Yes	0
SFTPA1-009 ENSP00000401649 ENST00000439264	A0A0C4DG36 [Direct mapping] Pulmonary surfactant-associated protein A1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		158 aa 16 kDa	Yes	0
SFTPA1-201 ENSP00000381633 ENST00000398636	Q8IWL2 [Direct mapping] Pulmonary surfactant-associated protein A1 A0A024QZP2 [Target identity:100%; Query identity:100%] Surfactant, pulmonary-associated protein A1, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	248 aa 26.2 kDa	Yes	0
SFTPA1-202 ENSP00000411102 ENST00000428376	Q8IWL2 [Direct mapping] Pulmonary surfactant-associated protein A1 A0A024QZP2 [Target identity:100%; Query identity:100%] Surfactant, pulmonary-associated protein A1, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	248 aa 26.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.