Tissue expression of SFTPA1 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SFTPA1
Gene description	Surfactant protein A1
Protein class	Disease related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (lung)
GTEx:	Tissue enriched (lung)
FANTOM5:	Tissue enriched (lung)

Protein evidence

Evidence at protein level

Protein expression

Highly specific cytoplasmic expression in type II pneumocytes.

DATA RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Supported based on 4 antibodies. HPA042638 , HPA045752 , HPA049368 , CAB016793
	SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (lung)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (lung)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (lung)

GENE INFORMATION
Gene name	SFTPA1 (HGNC Symbol)
Synonyms	COLEC4, SFTP1, SP-A, SP-A1
Description	Surfactant protein A1 (HGNC Symbol)
Entrez gene summary	This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in this gene are associated with idiopathic pulmonary fibrosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Chromosome	10
Cytoband	q22.3
Chromosome location (bp)	79610939 - 79615455
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122852 (version 83.38)
Entrez gene	653509
UniProt	Q8IWL2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWL2
Antibodypedia	SFTPA1 antibodies

PROTEIN BROWSER

SFTPA1-007	SFTPA1-008	SFTPA1-009	SFTPA1-201	SFTPA1-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SFTPA1-007 ENSP00000395527 ENST00000429958	A0A0C4DG36 [Direct mapping] Pulmonary surfactant-associated protein A1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		158 aa 16 kDa	Yes	0
SFTPA1-008 ENSP00000397082 ENST00000419470	Q8IWL2 [Direct mapping] Pulmonary surfactant-associated protein A1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	263 aa 27.7 kDa	Yes	0
SFTPA1-009 ENSP00000401649 ENST00000439264	A0A0C4DG36 [Direct mapping] Pulmonary surfactant-associated protein A1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		158 aa 16 kDa	Yes	0
SFTPA1-201 ENSP00000381633 ENST00000398636	Q8IWL2 [Direct mapping] Pulmonary surfactant-associated protein A1 A0A024QZP2 [Target identity:100%; Query identity:100%] Surfactant, pulmonary-associated protein A1, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	248 aa 26.2 kDa	Yes	0
SFTPA1-202 ENSP00000411102 ENST00000428376	Q8IWL2 [Direct mapping] Pulmonary surfactant-associated protein A1 A0A024QZP2 [Target identity:100%; Query identity:100%] Surfactant, pulmonary-associated protein A1, isoform CRA_b Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Show all	GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0005581 [collagen trimer] GO:0005615 [extracellular space] GO:0005789 [endoplasmic reticulum membrane] GO:0006869 [lipid transport] GO:0007585 [respiratory gaseous exchange] GO:0030246 [carbohydrate binding] GO:0042599 [lamellar body] GO:0044267 [cellular protein metabolic process] GO:0045334 [clathrin-coated endocytic vesicle] Show all	248 aa 26.2 kDa	Yes	0