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A few cases of malignant melanomas, liver, colorectal and skin cancers along with rare case of ovarian, stomach and urothelial showed moderate nuclear and cytoplasmic staining. A single case of duct carcinoma of breast showed moderate membranous staining. Remaining malignant cells were mainly negative.
GENE INFORMATION
Gene name
CISD1 (HGNC Symbol)
Synonyms
C10orf70, MDS029, mitoNEET, ZCD1
Description
CDGSH iron sulfur domain 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]
