Cell atlas - CISD1 - The Human Protein Atlas

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CISD1

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Mitochondria

Human cell
	Mitochondria

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GENERAL INFORMATION
Gene name	CISD1
Gene description	CDGSH iron sulfur domain 1
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the mitochondria.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Mitochondria (supported)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA074383
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the mitochondria.

Main location

Mitochondria (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA074383	PC-3	Mitochondria
	HPA074383	U-2 OS	Mitochondria

GENE INFORMATION
Gene name	CISD1 (HGNC Symbol)
Synonyms	C10orf70, MDS029, mitoNEET, ZCD1
Description	CDGSH iron sulfur domain 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein with a CDGSH iron-sulfur domain and has been shown to bind a redox-active [2Fe-2S] cluster. The encoded protein has been localized to the outer membrane of mitochondria and is thought to play a role in regulation of oxidation. Genes encoding similar proteins are located on chromosomes 4 and 17, and a pseudogene of this gene is located on chromosome 2. [provided by RefSeq, Feb 2012]
Chromosome	10
Cytoband	q21.1
Chromosome location (bp)	58269058 - 58289586
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000122873 (version 83.38)
Entrez gene	55847
UniProt	Q9NZ45 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NZ45
Antibodypedia	CISD1 antibodies

PROTEIN BROWSER

CISD1-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CISD1-001 ENSP00000363041 ENST00000333926	Q9NZ45 [Direct mapping] CDGSH iron-sulfur domain-containing protein 1 A0A024QZN7 [Target identity:100%; Query identity:100%] Chromosome 10 open reading frame 70, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0043457 [regulation of cellular respiration] GO:0046872 [metal ion binding] GO:0051537 [2 iron, 2 sulfur cluster binding] GO:0070062 [extracellular exosome] Show all	108 aa 12.2 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.