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VPS26A

CANCER ATLAS

Gene description

 VPS26 retromer complex component A

Protein class

 Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA057498
CAB011602
CAB075733

GENE INFORMATION

Gene name

 VPS26A (HGNC Symbol)

Synonyms

 Hbeta58, PEP8A, VPS26

Description

 VPS26 retromer complex component A (HGNC Symbol)

Entrez gene summary

 This gene belongs to a group of vacuolar protein sorting (VPS) genes. The encoded protein is a component of a large multimeric complex, termed the retromer complex, involved in retrograde transport of proteins from endosomes to the trans-Golgi network. The close structural similarity between the yeast and human proteins that make up this complex suggests a similarity in function. Expression studies in yeast and mammalian cells indicate that this protein interacts directly with VPS35, which serves as the core of the retromer complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q22.1

Chromosome location (bp)

 69123512 - 69172861

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000122958 (version 83.38)

Entrez gene

 9559

UniProt

 O75436 (UniProt - Evidence at protein level)

neXtProt

 NX_O75436

Antibodypedia

 VPS26A antibodies

PROTEIN BROWSER
VPS26A-001
VPS26A-002
VPS26A-201
VPS26A-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
VPS26A-001
ENSP00000362480
ENST00000373382
O75436 [Direct mapping]
Vacuolar protein sorting-associated protein 26A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0010008 [endosome membrane]
GO:0030904 [retromer complex]
GO:0030906 [retromer, cargo-selective complex]
GO:0031982 [vesicle]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0070062 [extracellular exosome]
GO:0097422 [tubular endosome]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 327 aa
38.2 kDa 		No 0
VPS26A-002
ENSP00000474611
ENST00000489794
S4R3Q6 [Direct mapping]
Vacuolar protein sorting-associated protein 26A
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005622 [intracellular]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0030904 [retromer complex]
Show all
 226 aa
26.2 kDa 		No 0
VPS26A-201
ENSP00000263559
ENST00000263559
O75436 [Direct mapping]
Vacuolar protein sorting-associated protein 26A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0010008 [endosome membrane]
GO:0030904 [retromer complex]
GO:0030906 [retromer, cargo-selective complex]
GO:0031982 [vesicle]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0070062 [extracellular exosome]
GO:0097422 [tubular endosome]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 327 aa
38.2 kDa 		No 0
VPS26A-202
ENSP00000378532
ENST00000395098
O75436 [Direct mapping]
Vacuolar protein sorting-associated protein 26A
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0008565 [protein transporter activity]
GO:0010008 [endosome membrane]
GO:0030904 [retromer complex]
GO:0030906 [retromer, cargo-selective complex]
GO:0031982 [vesicle]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0070062 [extracellular exosome]
GO:0097422 [tubular endosome]
GO:1990126 [retrograde transport, endosome to plasma membrane]
Show all
 251 aa
28.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.