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Cancer tissues displayed moderate to strong cytoplasmic staining. Several cases of lymphoma, testicular and renal cancers were weakly stained or negative.
Cancer tissues showed weak to moderate cytoplasmic staining which in fractions of cases was combined with membranous positivity. Cases of ovarian cancers displayed strong positivity. A majority of gliomas, lymphomas, testicular and lung cancers were negative.
GENE INFORMATION
Gene name
RASSF8 (HGNC Symbol)
Synonyms
C12orf2, HoJ-1
Description
Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]