Tissue expression of RASSF8 - Summary - The Human Protein Atlas

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RASSF8

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	RASSF8
Gene description	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
Protein class	Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (testis)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA038163 , HPA038164
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	RASSF8 (HGNC Symbol)
Synonyms	C12orf2, HoJ-1
Description	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the Ras-assocation domain family (RASSF) of tumor suppressor proteins. This gene is essential for maintaining adherens junction function in epithelial cells and has a role in epithelial cell migration. It is a lung tumor suppressor gene candidate. A chromosomal translocation t(12;22)(p11.2;q13.3) leading to the fusion of this gene and the FBLN1 gene is found in a complex type of synpolydactyly. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]
Chromosome	12
Cytoband	p12.1
Chromosome location (bp)	25959029 - 26079892
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123094 (version 83.38)
Entrez gene	11228
UniProt	Q8NHQ8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NHQ8
Antibodypedia	RASSF8 antibodies

PROTEIN BROWSER

RASSF8-001	RASSF8-002	RASSF8-003	RASSF8-005	RASSF8-006	RASSF8-007	RASSF8-008	RASSF8-010	RASSF8-011	RASSF8-013	RASSF8-201	RASSF8-202	RASSF8-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RASSF8-001 ENSP00000370756 ENST00000381352	Q8NHQ8 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	392 aa 45.4 kDa	No	0
RASSF8-002 ENSP00000384491 ENST00000405154	Q8NHQ8 [Direct mapping] Ras association domain-containing protein 8 A0A024RB12 [Target identity:100%; Query identity:100%] Ras association (RalGDS/AF-6) domain family 8, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	419 aa 48.3 kDa	No	0
RASSF8-003 ENSP00000282884 ENST00000282884	Q8NHQ8 [Direct mapping] Ras association domain-containing protein 8 A0A024RB12 [Target identity:100%; Query identity:100%] Ras association (RalGDS/AF-6) domain family 8, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	419 aa 48.3 kDa	No	0
RASSF8-005 ENSP00000445434 ENST00000537946	F5H343 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	29 aa 3.2 kDa	No	0
RASSF8-006 ENSP00000443696 ENST00000545413	F5H8C5 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	159 aa 18.1 kDa	No	0
RASSF8-007 ENSP00000445970 ENST00000541218	F5H0S5 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	208 aa 24 kDa	No	0
RASSF8-008 ENSP00000439839 ENST00000542865	Q8NHQ8 [Direct mapping] Ras association domain-containing protein 8 A0A024RB12 [Target identity:100%; Query identity:100%] Ras association (RalGDS/AF-6) domain family 8, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	419 aa 48.3 kDa	No	0
RASSF8-010 ENSP00000442485 ENST00000542004	F5H7J1 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	219 aa 25.4 kDa	No	0
RASSF8-011 ENSP00000441294 ENST00000542315	F5GYP8 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	122 aa 13.9 kDa	No	0
RASSF8-013 ENSP00000442036 ENST00000535907	F5H8B9 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	91 aa 10.3 kDa	No	0
RASSF8-201 ENSP00000443096 ENST00000541490	Q8NHQ8 [Direct mapping] Ras association domain-containing protein 8 A0A024RB12 [Target identity:100%; Query identity:100%] Ras association (RalGDS/AF-6) domain family 8, isoform CRA_b Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	419 aa 48.3 kDa	No	0
RASSF8-202 ENSP00000478107 ENST00000611440	Q6IB99 [Direct mapping] C12orf2 protein; Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	109 aa 12.4 kDa	No	0
RASSF8-203 ENSP00000481417 ENST00000615708	Q8NHQ8 [Direct mapping] Ras association domain-containing protein 8 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	392 aa 45.4 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.