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NECAB1

GENERAL INFORMATION

Gene name

 NECAB1

Gene description

 N-terminal EF-hand calcium binding protein 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (cerebral cortex)
GTEx:Group enriched (cerebral cortex, hippocampus, hypothalamus, caudate)
FANTOM5:Group enriched (brain, caudate, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in CNS, peripheral nerves and renal glomeruli.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 7 antibodies.
HPA023252 , HPA023629 , HPA025963 , HPA031262 , CAB068208 , CAB068209 , CAB068210
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Hippocampus

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical
Cerebral cortexHippocampusCaudateCerebellumThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleNasopharynxBronchusLungLiverGallbladderPancreasOral mucosaSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSoft tissueSkinNotdetectedLowMediumHighSCORE

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (cerebral cortex)
Cerebral cortexThyroid glandParathyroid glandAdrenal glandAppendixBone marrowLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusStomachDuodenumSmall intestineColonRectumKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastCervix, uterineEndometriumFallopian tubeOvaryPlacentaAdipose tissueSkin020406080TPM
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebral cortex, hippocampus, hypothalamus, caudate)
HypothalamusPituitary glandCerebral cortexHippocampusCaudateCerebellumThyroid glandAdrenal glandSpleenHeart muscleSkeletal muscleLungLiverPancreasSalivary glandEsophagusStomachSmall intestineColonKidneyUrinary bladderTestisProstateBreastVaginaCervix, uterineEndometriumFallopian tubeOvaryAdipose tissueSkin0246810RPKM
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (brain, caudate, hippocampus)
Pituitary glandBrainHippocampusCaudateCerebellumThyroid glandAppendixLymph nodeTonsilSpleenHeart muscleSkeletal muscleSmooth muscleLungLiverGallbladderPancreasSalivary glandEsophagusSmall intestineColonKidneyUrinary bladderTestisEpididymisProstateSeminal vesicleBreastVaginaCervix, uterineEndometriumOvaryPlacentaAdipose tissueRetina050100150200250300Tags Per Million

GENE INFORMATION

Gene name

 NECAB1 (HGNC Symbol)

Synonyms

 EFCBP1

Description

 N-terminal EF-hand calcium binding protein 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 8

Cytoband

 q21.3

Chromosome location (bp)

 90791550 - 90959408

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123119 (version 83.38)

Entrez gene

 64168

UniProt

 Q8N987 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8N987

Antibodypedia

 NECAB1 antibodies

PROTEIN BROWSER
NECAB1-001
NECAB1-003
NECAB1-007

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NECAB1-001
ENSP00000387380
ENST00000417640
Q8N987 [Direct mapping]
N-terminal EF-hand calcium-binding protein 1
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0042984 [regulation of amyloid precursor protein biosynthetic process]
Show all
 351 aa
40.6 kDa 		No 0
NECAB1-003
ENSP00000428632
ENST00000521366
Q8N987 [Direct mapping]
N-terminal EF-hand calcium-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0042984 [regulation of amyloid precursor protein biosynthetic process]
Show all
 100 aa
11.8 kDa 		No 0
NECAB1-007
ENSP00000428953
ENST00000522820
Q8N987 [Direct mapping]
N-terminal EF-hand calcium-binding protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005509 [calcium ion binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0042984 [regulation of amyloid precursor protein biosynthetic process]
Show all
 100 aa
11.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.