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Malignant cells showed a variable staining pattern. A few cases of pancreatic cancers displayed strong cytoplasmic staining. Many cases of squamous cell carcinomas, colorectal and breast cancers along with a few cases of prostate, urothelial, renal and pancreatic cancers expressed moderate staining. Remaining malignant cells were either negative or weakly stained.
Malignant tissues generally showed weak cytoplasmic immunoreactivity or were negative. Moderate staining was observed mainly in breast and ovarian cancers.
GENE INFORMATION
Gene name
ATXN3L (HGNC Symbol)
Synonyms
MJDL
Description
Ataxin 3-like (HGNC Symbol)
Entrez gene summary
This intronless gene may be a pseudogene (PMID:11450850). This gene is similar to the multi-exon gene which encodes ataxin 3 and contains a coding region which could encode a protein similar to ataxin 3. Mutations in the gene encoding ataxin 3 are associated with Machado-Joseph disease. [provided by RefSeq, Sep 2011]