Fields »
ABOUT
HELP
BLOG
TTC21B

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 TTC21B

Gene description

 Tetratricopeptide repeat domain 21B

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Single-cell variation

 Single-cell variation in protein expression observed.

DATA RELIABILITY

Reliability score

 Supported based on 2 antibodies.
HPA035494 , HPA035495
SHOW MORE

ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria.

Main location

 Mitochondria (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA035494 A-431 Mitochondria Intensity
HPA035494 U-2 OS Mitochondria Intensity
HPA035495 A-431 Mitochondria
HPA035495 Hep G2 No staining    
HPA035495 U-2 OS Mitochondria
Cytosol

GENE INFORMATION

Gene name

 TTC21B (HGNC Symbol)

Synonyms

 FLJ11457, IFT139B, JBTS11, NPHP12, THM1

Description

 Tetratricopeptide repeat domain 21B (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of TTC21 family, containing several tetratricopeptide repeat (TPR) domains. This protein is localized to the cilium axoneme, and may play a role in retrograde intraflagellar transport in cilia. Mutations in this gene are associated with various ciliopathies, nephronophthisis 12, and asphyxiating thoracic dystrophy 4. [provided by RefSeq, Oct 2011]

Chromosome

 2

Cytoband

 q24.3

Chromosome location (bp)

 165857475 - 165953843

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123607 (version 83.38)

Entrez gene

 79809

UniProt

 Q7Z4L5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7Z4L5

Antibodypedia

 TTC21B antibodies

PROTEIN BROWSER
TTC21B-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TTC21B-001
ENSP00000243344
ENST00000243344
Q7Z4L5 [Direct mapping]
Tetratricopeptide repeat protein 21B
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005856 [cytoskeleton]
GO:0005929 [cilium]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006996 [organelle organization]
GO:0007224 [smoothened signaling pathway]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0021591 [ventricular system development]
GO:0021798 [forebrain dorsal/ventral pattern formation]
GO:0030991 [intraciliary transport particle A]
GO:0035721 [intraciliary retrograde transport]
GO:0035735 [intraciliary transport involved in cilium morphogenesis]
GO:0060271 [cilium morphogenesis]
GO:0061512 [protein localization to cilium]
GO:0072372 [primary cilium]
GO:0097542 [ciliary tip]
Show all
 1316 aa
150.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.