Expression of NMI in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

N-myc (and STAT) interactor

Protein class

Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA008588

GENE INFORMATION
Gene name	NMI
Synonyms
Description	N-myc (and STAT) interactor (HGNC Symbol)
Entrez gene summary	NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q23.3
Chromosome location (bp)	151270465 - 151290057
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000123609 (version 83.38)
Entrez gene	9111
UniProt	Q13287 (UniProt - Evidence at protein level)
neXtProt	NX_Q13287
Antibodypedia	NMI antibodies

PROTEIN BROWSER

NMI-001	NMI-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NMI-001 ENSP00000243346 ENST00000243346	Q13287 [Direct mapping] N-myc-interactor Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006954 [inflammatory response] GO:0007259 [JAK-STAT cascade] GO:0032480 [negative regulation of type I interferon production] GO:0045355 [negative regulation of interferon-alpha biosynthetic process] GO:0045358 [negative regulation of interferon-beta biosynthetic process] GO:0045824 [negative regulation of innate immune response] GO:1902524 [positive regulation of protein K48-linked ubiquitination] GO:1903506 [regulation of nucleic acid-templated transcription] Show all	307 aa 35.1 kDa	No	0
NMI-003 ENSP00000387373 ENST00000414946	C9JW17 [Direct mapping] N-myc-interactor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		29 aa 3.4 kDa	No	0