Moderate cytoplasmic positivity was observed in several prostate and pancreatic cancers. Remaining cancers were in general weakly stained or negative.
ACVR1C (HGNC Symbol)
Activin A receptor, type IC (HGNC Symbol)
Entrez gene summary
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]