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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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ACVR1C
  • TISSUE

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  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLAS

Gene description

Activin A receptor, type IC

Protein class

Enzymes, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA007982
HPA011933

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of malignant cells were moderately stained. Testicular cancers exhibited strong immunoreactivity.

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Moderate cytoplasmic positivity was observed in several prostate and pancreatic cancers. Remaining cancers were in general weakly stained or negative.

GENE INFORMATION

Gene name

ACVR1C (HGNC Symbol)

Synonyms

ACVRLK7, ALK7

Description

Activin A receptor, type IC (HGNC Symbol)

Entrez gene summary

ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Chromosome

2

Cytoband

q24.1

Chromosome location (bp)

157526767 - 157629005

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000123612 (version 83.38)

Entrez gene

130399

UniProt

Q8NER5 (UniProt - Evidence at protein level)

neXtProt

NX_Q8NER5

Antibodypedia

ACVR1C antibodies

PROTEIN BROWSER

ACVR1C-001
ACVR1C-002
ACVR1C-003
ACVR1C-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACVR1C-001
ENSP00000243349
ENST00000243349
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002021 [response to dietary excess]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0009749 [response to glucose]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0019915 [lipid storage]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0032868 [response to insulin]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
493 aa
54.9 kDa
Yes 1
ACVR1C-002
ENSP00000335139
ENST00000348328
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
336 aa
37.5 kDa
Yes 0
ACVR1C-003
ENSP00000335178
ENST00000335450
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
413 aa
46.4 kDa
Yes 0
ACVR1C-004
ENSP00000387168
ENST00000409680
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
443 aa
49.7 kDa
No 1

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