Fields »
ABOUT
HELP
BLOG
ACVR1C

Please wait until image is loaded before changing channels

GENERAL INFORMATION

Gene name

 ACVR1C

Gene description

 Activin A receptor, type IC

Protein class

 Enzymes
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Membrane,Secreted

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (HDLM-2)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HDLM-2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 ACVR1C (HGNC Symbol)

Synonyms

 ACVRLK7, ALK7

Description

 Activin A receptor, type IC (HGNC Symbol)

Entrez gene summary

 ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]

Chromosome

 2

Cytoband

 q24.1

Chromosome location (bp)

 157526767 - 157629005

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123612 (version 83.38)

Entrez gene

 130399

UniProt

 Q8NER5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NER5

Antibodypedia

 ACVR1C antibodies

PROTEIN BROWSER
ACVR1C-001
ACVR1C-002
ACVR1C-003
ACVR1C-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ACVR1C-001
ENSP00000243349
ENST00000243349
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0002021 [response to dietary excess]
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0009749 [response to glucose]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0019915 [lipid storage]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0032868 [response to insulin]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046676 [negative regulation of insulin secretion]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 493 aa
54.9 kDa 		Yes 1
ACVR1C-002
ENSP00000335139
ENST00000348328
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 336 aa
37.5 kDa 		Yes 0
ACVR1C-003
ENSP00000335178
ENST00000335450
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 413 aa
46.4 kDa 		Yes 0
ACVR1C-004
ENSP00000387168
ENST00000409680
Q8NER5 [Direct mapping]
Activin receptor type-1C
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   TKL Ser/Thr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0004675 [transmembrane receptor protein serine/threonine kinase activity]
GO:0004702 [receptor signaling protein serine/threonine kinase activity]
GO:0005524 [ATP binding]
GO:0005886 [plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0016020 [membrane]
GO:0016361 [activin receptor activity, type I]
GO:0019838 [growth factor binding]
GO:0023014 [signal transduction by protein phosphorylation]
GO:0030154 [cell differentiation]
GO:0030262 [apoptotic nuclear changes]
GO:0038092 [nodal signaling pathway]
GO:0038100 [nodal binding]
GO:0043280 [positive regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0046872 [metal ion binding]
GO:0048179 [activin receptor complex]
GO:1901164 [negative regulation of trophoblast cell migration]
GO:1901383 [negative regulation of chorionic trophoblast cell proliferation]
Show all
 443 aa
49.7 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.