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PFKFB2

GENERAL INFORMATION

Gene name

 PFKFB2

Gene description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA049975
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Oral mucosa
N/A
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 PFKFB2

Synonyms

Description

 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 q32.1

Chromosome location (bp)

 207034366 - 207081024

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000123836 (version 83.38)

Entrez gene

 5208

UniProt

 O60825 (UniProt - Evidence at protein level)

neXtProt

 NX_O60825

Antibodypedia

 PFKFB2 antibodies

PROTEIN BROWSER
PFKFB2-001
PFKFB2-002
PFKFB2-009
PFKFB2-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PFKFB2-001
ENSP00000356047
ENST00000367080
O60825 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006007 [glucose catabolic process]
GO:0006089 [lactate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0006096 [glycolytic process]
GO:0008152 [metabolic process]
GO:0009749 [response to glucose]
GO:0016311 [dephosphorylation]
GO:0019900 [kinase binding]
GO:0019901 [protein kinase binding]
GO:0032024 [positive regulation of insulin secretion]
GO:0033133 [positive regulation of glucokinase activity]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 505 aa
58.5 kDa 		No 0
PFKFB2-002
ENSP00000356046
ENST00000367079
O60825 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 6-phosphofructo-2-kinase Fructose-2,6-bisphosphatase
Show all
Enzymes
   ENZYME proteins
   Transferases
   Hydrolases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0004331 [fructose-2,6-bisphosphate 2-phosphatase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006096 [glycolytic process]
GO:0008152 [metabolic process]
GO:0016311 [dephosphorylation]
GO:0019901 [protein kinase binding]
GO:0044281 [small molecule metabolic process]
GO:0046835 [carbohydrate phosphorylation]
GO:0061621 [canonical glycolysis]
Show all
 471 aa
54.4 kDa 		No 0
PFKFB2-009
ENSP00000484988
ENST00000618513
A0A087X2H4 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0005524 [ATP binding]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
Show all
 49 aa
5.4 kDa 		No 0
PFKFB2-010
ENSP00000439420
ENST00000545806
F6RAZ1 [Direct mapping]
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003873 [6-phosphofructo-2-kinase activity]
GO:0005524 [ATP binding]
GO:0006000 [fructose metabolic process]
GO:0006003 [fructose 2,6-bisphosphate metabolic process]
GO:0046835 [carbohydrate phosphorylation]
Show all
 125 aa
14.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.