Cell atlas - PI3 - The Human Protein Atlas

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PI3

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TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Plasma membrane

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	PI3
Gene description	Peptidase inhibitor 3, skin-derived
Protein class	Plasma proteins Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane.
RNA cell category	Group enriched (PC-3, HaCaT, EFO-21)
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. CAB009449
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (PC-3, HaCaT, EFO-21) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane.

Main location

Plasma membrane (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	CAB009449	PC-3	Plasma membrane
	CAB009449	U-2 OS	Plasma membrane

GENE INFORMATION
Gene name	PI3 (HGNC Symbol)
Synonyms	cementoin, ELAFIN, ESI, SKALP, WAP3, WFDC14
Description	Peptidase inhibitor 3, skin-derived (HGNC Symbol)
Entrez gene summary	This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45174876 - 45176544
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124102 (version 83.38)
Entrez gene	5266
UniProt	P19957 (UniProt - Evidence at protein level)
neXtProt	NX_P19957
Antibodypedia	PI3 antibodies

PROTEIN BROWSER

PI3-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PI3-001 ENSP00000243924 ENST00000243924	P19957 [Direct mapping] Elafin Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004866 [endopeptidase inhibitor activity] GO:0004867 [serine-type endopeptidase inhibitor activity] GO:0005576 [extracellular region] GO:0005578 [proteinaceous extracellular matrix] GO:0007620 [copulation] GO:0010951 [negative regulation of endopeptidase activity] GO:0030414 [peptidase inhibitor activity] GO:0070062 [extracellular exosome] Show all	117 aa 12.3 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.