Expression of DDX27 in cancer - Summary

CANCER ATLAS

Gene description

DEAD (Asp-Glu-Ala-Asp) box polypeptide 27

Protein class

Enzymes, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA047087

GENE INFORMATION
Gene name	DDX27 (HGNC Symbol)
Synonyms	dJ686N3.1, DRS1
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	49219295 - 49244077
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124228 (version 83.38)
Entrez gene	55661
UniProt	Q96GQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GQ7
Antibodypedia	DDX27 antibodies

PROTEIN BROWSER

DDX27-001	DDX27-005	DDX27-007	DDX27-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX27-001 ENSP00000360828 ENST00000371764	Q96GQ7 [Direct mapping] Probable ATP-dependent RNA helicase DDX27 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0044822 [poly(A) RNA binding] Show all	796 aa 89.8 kDa	No	0
DDX27-005 ENSP00000483119 ENST00000493252	A0A087X059 [Direct mapping] Probable ATP-dependent RNA helicase DDX27 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	275 aa 30.2 kDa	No	0
DDX27-007 ENSP00000482680 ENST00000618172	B7Z6D5 [Direct mapping] Probable ATP-dependent RNA helicase DDX27; cDNA FLJ61659, highly similar to Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	765 aa 86.6 kDa	No	0
DDX27-201 ENSP00000483495 ENST00000622530	Q96GQ7 [Direct mapping] Probable ATP-dependent RNA helicase DDX27 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0044822 [poly(A) RNA binding] Show all	796 aa 89.8 kDa	No	0