Cell atlas - DDX27 - The Human Protein Atlas

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DDX27

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	DDX27
Gene description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047087
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA047087	A-431	Nucleoli
	HPA047087	U-2 OS	Nucleoli
	HPA047087	U-251 MG	Nucleoli

GENE INFORMATION
Gene name	DDX27 (HGNC Symbol)
Synonyms	dJ686N3.1, DRS1
Description	DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 (HGNC Symbol)
Entrez gene summary	DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, the function of which has not been determined. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.13
Chromosome location (bp)	49219295 - 49244077
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124228 (version 83.38)
Entrez gene	55661
UniProt	Q96GQ7 (UniProt - Evidence at protein level)
neXtProt	NX_Q96GQ7
Antibodypedia	DDX27 antibodies

PROTEIN BROWSER

DDX27-001	DDX27-005	DDX27-007	DDX27-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DDX27-001 ENSP00000360828 ENST00000371764	Q96GQ7 [Direct mapping] Probable ATP-dependent RNA helicase DDX27 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0044822 [poly(A) RNA binding] Show all	796 aa 89.8 kDa	No	0
DDX27-005 ENSP00000483119 ENST00000493252	A0A087X059 [Direct mapping] Probable ATP-dependent RNA helicase DDX27 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	275 aa 30.2 kDa	No	0
DDX27-007 ENSP00000482680 ENST00000618172	B7Z6D5 [Direct mapping] Probable ATP-dependent RNA helicase DDX27; cDNA FLJ61659, highly similar to Probable ATP-dependent RNA helicase DDX27 (EC 3.6.1.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0010501 [RNA secondary structure unwinding] Show all	765 aa 86.6 kDa	No	0
DDX27-201 ENSP00000483495 ENST00000622530	Q96GQ7 [Direct mapping] Probable ATP-dependent RNA helicase DDX27 Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0004004 [ATP-dependent RNA helicase activity] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0010501 [RNA secondary structure unwinding] GO:0044822 [poly(A) RNA binding] Show all	796 aa 89.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.