Expression of RBPJL in cancer - Summary

CANCER ATLAS

Gene description

Recombination signal binding protein for immunoglobulin kappa J region-like

Protein class

Predicted intracellular proteins, Transcription factors

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

STAINING SUMMARY

CAB006846

GENE INFORMATION
Gene name	RBPJL (HGNC Symbol)
Synonyms	RBP-L, RBPSUHL, SUH, SUHL
Description	Recombination signal binding protein for immunoglobulin kappa J region-like (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	45306851 - 45317824
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124232 (version 83.38)
Entrez gene	11317
UniProt	Q9UBG7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UBG7
Antibodypedia	RBPJL antibodies

PROTEIN BROWSER

RBPJL-001	RBPJL-002	RBPJL-003	RBPJL-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBPJL-001 ENSP00000361828 ENST00000372743	Q9UBG7 [Direct mapping] Recombining binding protein suppressor of hairless-like protein Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] Show all	516 aa 56.6 kDa	No	0
RBPJL-002 ENSP00000341243 ENST00000343694	Q9UBG7 [Direct mapping] Recombining binding protein suppressor of hairless-like protein Show all	Predicted intracellular proteins Transcription factors Immunoglobulin fold Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005667 [transcription factor complex] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0007165 [signal transduction] GO:0045893 [positive regulation of transcription, DNA-templated] Show all	517 aa 56.8 kDa	No	0
RBPJL-003 ENSP00000361826 ENST00000372741	Q5QPV1 [Direct mapping] Recombining binding protein suppressor of hairless (Drosophila)-like, isoform CRA_a; Recombining-binding protein suppressor of hairless-like protein Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	471 aa 51.3 kDa	No	0
RBPJL-004 ENSP00000483978 ENST00000464504	A0A087X185 [Direct mapping] Recombining-binding protein suppressor of hairless-like protein Show all	Predicted intracellular proteins Show all	GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] Show all	184 aa 19.5 kDa	No	0