Cell atlas - MAGEA10 - The Human Protein Atlas

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MAGEA10

TISSUE

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CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

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GENERAL INFORMATION
Gene name	MAGEA10
Gene description	Melanoma antigen family A10
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Group enriched (WM-115, PC-3, SH-SY5Y, U-266/84)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (supported)
Additional location	In addition localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA070780
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (WM-115, PC-3, SH-SY5Y, U-266/84) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (supported)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA070780	PC-3	No staining
	HPA070780	SH-SY5Y	Nucleoplasm
	HPA070780	SH-SY5Y	Cytosol

GENE INFORMATION
Gene name	MAGEA10 (HGNC Symbol)
Synonyms	CT1.10, MAGE10, MGC10599
Description	Melanoma antigen family A10 (HGNC Symbol)
Entrez gene summary	This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]
Chromosome	X
Cytoband	q28
Chromosome location (bp)	152133310 - 152138578
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124260 (version 83.38)
Entrez gene	4109
UniProt	P43363 (UniProt - Evidence at transcript level)
neXtProt	NX_P43363
Antibodypedia	MAGEA10 antibodies

PROTEIN BROWSER

MAGEA10-001	MAGEA10-002	MAGEA10-003	MAGEA10-004	MAGEA10-005	MAGEA10-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAGEA10-001 ENSP00000359347 ENST00000370323	P43363 [Direct mapping] Melanoma-associated antigen 10 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	369 aa 40.8 kDa	No	0
MAGEA10-002 ENSP00000391977 ENST00000427322	C9J9A2 [Direct mapping] Melanoma-associated antigen 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		161 aa 17.2 kDa	No	0
MAGEA10-003 ENSP00000406161 ENST00000444834	C9J958 [Direct mapping] Melanoma-associated antigen 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		184 aa 19.9 kDa	No	0
MAGEA10-004 ENSP00000464160 ENST00000583480	J3QRD7 [Direct mapping] Melanoma-associated antigen 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.4 kDa	No	0
MAGEA10-005 ENSP00000462833 ENST00000579960	J3KT71 [Direct mapping] Melanoma-associated antigen 10 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.1 kDa	No	0
MAGEA10-201 ENSP00000244096 ENST00000244096	P43363 [Direct mapping] Melanoma-associated antigen 10 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] Show all	369 aa 40.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.