Tissue expression of IRGC - Summary - The Human Protein Atlas

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IRGC

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TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	IRGC
Gene description	Immunity-related GTPase family, cinema
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (testis)
GTEx:	Tissue enriched (testis)
FANTOM5:	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in spermatozoa.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA046769 , HPA060064
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (testis)

GENE INFORMATION
Gene name	IRGC (HGNC Symbol)
Synonyms	CINEMA, Iigp5, IRGC1
Description	Immunity-related GTPase family, cinema (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43716010 - 43720021
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124449 (version 83.38)
Entrez gene	56269
UniProt	Q6NXR0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q6NXR0
Antibodypedia	IRGC antibodies

PROTEIN BROWSER

IRGC-001	IRGC-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IRGC-001 ENSP00000244314 ENST00000244314	Q6NXR0 [Direct mapping] Interferon-inducible GTPase 5 J7NNX4 [Target identity:100%; Query identity:100%] Immunity-related GTPase family, cinema, isoform CRA_b; Interferon-gamma-inducible GTPase IFGGE protein Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005525 [GTP binding] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016787 [hydrolase activity] Show all	463 aa 50.3 kDa	No	0
IRGC-002 ENSP00000471425 ENST00000596627	M0R0T1 [Direct mapping] Interferon-inducible GTPase 5 Show all	Predicted intracellular proteins Show all	GO:0005525 [GTP binding] GO:0016020 [membrane] Show all	275 aa 30.2 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.