Cell atlas - GNMT - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GNMT

premium

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	GNMT
Gene description	Glycine N-methyltransferase
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (SCLC-21H)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA027501
	SHOW MORE

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (SCLC-21H) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA027501	A-431	Cytosol
	HPA027501	U-2 OS	Cytosol
	HPA027501	U-251 MG	Cytosol

GENE INFORMATION
Gene name	GNMT
Synonyms
Description	Glycine N-methyltransferase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is an enzyme that catalyzes the conversion of S-adenosyl-L-methionine (along with glycine) to S-adenosyl-L-homocysteine and sarcosine. The encoded protein is found in the cytoplasm and acts as a homotetramer. Defects in this gene are a cause of GNMT deficiency (hypermethioninemia). [provided by RefSeq, Oct 2008]
Chromosome	6
Cytoband	p21.1
Chromosome location (bp)	42960758 - 42963880
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000124713 (version 83.38)
Entrez gene	27232
UniProt	Q14749 (UniProt - Evidence at protein level)
neXtProt	NX_Q14749
Antibodypedia	GNMT antibodies

PROTEIN BROWSER

GNMT-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GNMT-001 ENSP00000361894 ENST00000372808	Q14749 [Direct mapping] Glycine N-methyltransferase V9HW60 [Target identity:100%; Query identity:100%] Glycine N-methyltransferase Show all	Enzymes ENZYME proteins Transferases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005542 [folic acid binding] GO:0005737 [cytoplasm] GO:0005977 [glycogen metabolic process] GO:0006111 [regulation of gluconeogenesis] GO:0006464 [cellular protein modification process] GO:0006555 [methionine metabolic process] GO:0006730 [one-carbon metabolic process] GO:0016594 [glycine binding] GO:0017174 [glycine N-methyltransferase activity] GO:0032259 [methylation] GO:0046500 [S-adenosylmethionine metabolic process] GO:0051289 [protein homotetramerization] Show all	295 aa 32.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.