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IL37

CANCER ATLAS

Gene description

 Interleukin 37

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA054371
HPA057950

GENE INFORMATION

Gene name

 IL37 (HGNC Symbol)

Synonyms

 FIL1, FIL1(ZETA), FIL1Z, IL-1F7, IL-1H4, IL-1RP1, IL1F7

Description

 Interleukin 37 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 2

Cytoband

 q14.1

Chromosome location (bp)

 112912971 - 112918882

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125571 (version 83.38)

Entrez gene

 27178

UniProt

 Q9NZH6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZH6

Antibodypedia

 IL37 antibodies

PROTEIN BROWSER
IL37-001
IL37-002
IL37-003
IL37-004
IL37-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IL37-001
ENSP00000263326
ENST00000263326
Q9NZH6 [Direct mapping]
Interleukin-37
Show all
Predicted intracellular proteins
Show all
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 218 aa
24.1 kDa 		No 0
IL37-002
ENSP00000263327
ENST00000352179
Q9NZH6 [Direct mapping]
Interleukin-37
Show all
Predicted intracellular proteins
Show all
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 197 aa
21.9 kDa 		No 0
IL37-003
ENSP00000263328
ENST00000349806
Q9NZH6 [Direct mapping]
Interleukin-37
Show all
Predicted intracellular proteins
Show all
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 157 aa
17.5 kDa 		No 0
IL37-004
ENSP00000309208
ENST00000353225
Q9NZH6 [Direct mapping]
Interleukin-37
Show all
Predicted intracellular proteins
Show all
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 178 aa
19.6 kDa 		No 0
IL37-005
ENSP00000309883
ENST00000311328
Q9NZH6 [Direct mapping]
Interleukin-37
Show all
Predicted intracellular proteins
Show all
GO:0002437 [inflammatory response to antigenic stimulus]
GO:0005125 [cytokine activity]
GO:0005149 [interleukin-1 receptor binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006955 [immune response]
GO:0019221 [cytokine-mediated signaling pathway]
Show all
 192 aa
21.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.