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Moderate cytoplasmic, luminal membranous and extra cellular staining was observed in endometrial cancer as well as in cases of ovarian, urothelial, liver and pancreatic cancers. Other cancer tissues were mainly negative.
A majority of malignant tissues displayed weak to moderate cytoplasmic staining. Most malignant lymphomas as well as several breast, cervical and skin cancers were negative.
Distinct positivity was observed in tumor stroma. Most malignant cells displayed weak to moderate cytoplasmic immunoreactivity. Strong staining was found in a few ovarian-, endometrial-, testicular- and renal cancers.
GENE INFORMATION
Gene name
C3 (HGNC Symbol)
Synonyms
ARMD9, C3a, C3b, CPAMD1
Description
Complement component 3 (HGNC Symbol)
Entrez gene summary
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients. [provided by RefSeq, Nov 2015]