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Most cancers displayed moderate cytoplasmic and nuclear staining. Membranous positivity was observed in few colorectal, pancreatic and thyroid cancers. Many testicular cancers along with a few urothelial, colorectal, breast and prostate cancers were strongly stained.
GENE INFORMATION
Gene name
SYMPK (HGNC Symbol)
Synonyms
SPK, SYM
Description
Symplekin (HGNC Symbol)
Entrez gene summary
This gene encodes a nuclear protein that functions in the regulation of polyadenylation and promotes gene expression. The protein forms a high-molecular weight complex with components of the polyadenylation machinery. It is thought to serve as a scaffold for recruiting regulatory factors to the polyadenylation complex. It also participates in 3'-end maturation of histone mRNAs, which do not undergo polyadenylation. The protein also localizes to the cytoplasmic plaques of tight junctions in some cell types. [provided by RefSeq, Jul 2008]
MEMSAT3 predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
