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Few cases of basal cell carcinomas of skin along with rare case of lung cancer displayed moderate to strong cytoplasmic and nuclear staining. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
TGM3 (HGNC Symbol)
Synonyms
TGE
Description
Transglutaminase 3 (HGNC Symbol)
Entrez gene summary
Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]
Q08188 [Direct mapping] Protein-glutamine gamma-glutamyltransferase E Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain
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Enzymes ENZYME proteins Transferases SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
