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TGM3

GENERAL INFORMATION

Gene name

 TGM3

Gene description

 Transglutaminase 3

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (esophagus)
GTEx:Tissue enriched (esophagus)
FANTOM5:Group enriched (tonsil, esophagus)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA004728
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Esophagus

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (esophagus)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (tonsil, esophagus)

GENE INFORMATION

Gene name

 TGM3 (HGNC Symbol)

Synonyms

 TGE

Description

 Transglutaminase 3 (HGNC Symbol)

Entrez gene summary

 Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene consists of two polypeptide chains activated from a single precursor protein by proteolysis. The encoded protein is involved the later stages of cell envelope formation in the epidermis and hair follicle. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 2296001 - 2341078

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125780 (version 83.38)

Entrez gene

 7053

UniProt

 Q08188 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08188

Antibodypedia

 TGM3 antibodies

PROTEIN BROWSER
TGM3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TGM3-001
ENSP00000370867
ENST00000381458
Q08188 [Direct mapping]
Protein-glutamine gamma-glutamyltransferase E Protein-glutamine gamma-glutamyltransferase E 50 kDa catalytic chain Protein-glutamine gamma-glutamyltransferase E 27 kDa non-catalytic chain
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Enzymes
   ENZYME proteins
   Transferases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003810 [protein-glutamine gamma-glutamyltransferase activity]
GO:0003824 [catalytic activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0006464 [cellular protein modification process]
GO:0016746 [transferase activity, transferring acyl groups]
GO:0018149 [peptide cross-linking]
GO:0030216 [keratinocyte differentiation]
GO:0031069 [hair follicle morphogenesis]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031424 [keratinization]
GO:0043163 [cell envelope organization]
GO:0051262 [protein tetramerization]
GO:0070062 [extracellular exosome]
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 693 aa
76.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.