Expression of CD93 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

CD93 molecule

Protein class

CD markers, Plasma proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA009300	HPA012368

GENE INFORMATION
Gene name	CD93 (HGNC Symbol)
Synonyms	C1qR(P), C1QR1, C1qRP, CDw93, dJ737E23.1, ECSM3, MXRA4
Description	CD93 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p11.21
Chromosome location (bp)	23079349 - 23086340
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125810 (version 83.38)
Entrez gene	22918
UniProt	Q9NPY3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NPY3
Antibodypedia	CD93 antibodies

PROTEIN BROWSER

CD93-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD93-002 ENSP00000246006 ENST00000246006	Q9NPY3 [Direct mapping] Complement component C1q receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001849 [complement component C1q binding] GO:0002230 [positive regulation of defense response to virus by host] GO:0004872 [receptor activity] GO:0004888 [transmembrane signaling receptor activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006909 [phagocytosis] GO:0009986 [cell surface] GO:0016021 [integral component of membrane] GO:0016023 [cytoplasmic membrane-bounded vesicle] GO:0016032 [viral process] GO:0016337 [single organismal cell-cell adhesion] GO:0030195 [negative regulation of blood coagulation] GO:0030246 [carbohydrate binding] GO:0042116 [macrophage activation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	652 aa 68.6 kDa	Yes	1