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NKX2-2

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GENERAL INFORMATION

Gene name

 NKX2-2

Gene description

 NK2 homeobox 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Cell line enhanced (U-138 MG, WM-115, T-47d, U-2 OS)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-138 MG, WM-115, T-47d, U-2 OS)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 NKX2-2 (HGNC Symbol)

Synonyms

 NKX2.2, NKX2B

Description

 NK2 homeobox 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p11.22

Chromosome location (bp)

 21511010 - 21514026

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125820 (version 83.38)

Entrez gene

 4821

UniProt

 O95096 (UniProt - Evidence at transcript level)

neXtProt

 NX_O95096

Antibodypedia

 NKX2-2 antibodies

PROTEIN BROWSER
NKX2-2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKX2-2-001
ENSP00000366347
ENST00000377142
O95096 [Direct mapping]
Homeobox protein Nkx-2.2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Show all
GO:0001159 [core promoter proximal region DNA binding]
GO:0003323 [type B pancreatic cell development]
GO:0003326 [pancreatic A cell fate commitment]
GO:0003327 [type B pancreatic cell fate commitment]
GO:0003329 [pancreatic PP cell fate commitment]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007224 [smoothened signaling pathway]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0008134 [transcription factor binding]
GO:0009749 [response to glucose]
GO:0010628 [positive regulation of gene expression]
GO:0014003 [oligodendrocyte development]
GO:0014070 [response to organic cyclic compound]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021529 [spinal cord oligodendrocyte cell differentiation]
GO:0021530 [spinal cord oligodendrocyte cell fate specification]
GO:0021554 [optic nerve development]
GO:0030154 [cell differentiation]
GO:0031018 [endocrine pancreas development]
GO:0032570 [response to progesterone]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048468 [cell development]
GO:0048565 [digestive tract development]
GO:0048665 [neuron fate specification]
GO:0048708 [astrocyte differentiation]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060580 [ventral spinal cord interneuron fate determination]
Show all
 273 aa
30.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.