Fields »
ABOUT
HELP
BLOG
NKX2-2

GENERAL INFORMATION

Gene name

 NKX2-2

Gene description

 NK2 homeobox 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, stomach)
GTEx:Group enriched (pituitary gland, hypothalamus, hippocampus, cerebral cortex, caudate, cerebellum, pancreas)
FANTOM5:Tissue enhanced (brain, cerebellum, hippocampus)

Protein evidence

 Evidence at protein level

Protein expression

 Nuclear and cytoplasmic expression in several tissues, including CNS.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA003468
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Rectum
N/A
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, stomach)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (pituitary gland, hypothalamus, hippocampus, cerebral cortex, caudate, cerebellum, pancreas)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (brain, cerebellum, hippocampus)

GENE INFORMATION

Gene name

 NKX2-2 (HGNC Symbol)

Synonyms

 NKX2.2, NKX2B

Description

 NK2 homeobox 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p11.22

Chromosome location (bp)

 21511010 - 21514026

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125820 (version 83.38)

Entrez gene

 4821

UniProt

 O95096 (UniProt - Evidence at transcript level)

neXtProt

 NX_O95096

Antibodypedia

 NKX2-2 antibodies

PROTEIN BROWSER
NKX2-2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NKX2-2-001
ENSP00000366347
ENST00000377142
O95096 [Direct mapping]
Homeobox protein Nkx-2.2
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Show all
GO:0001159 [core promoter proximal region DNA binding]
GO:0003323 [type B pancreatic cell development]
GO:0003326 [pancreatic A cell fate commitment]
GO:0003327 [type B pancreatic cell fate commitment]
GO:0003329 [pancreatic PP cell fate commitment]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007224 [smoothened signaling pathway]
GO:0007399 [nervous system development]
GO:0007420 [brain development]
GO:0008134 [transcription factor binding]
GO:0009749 [response to glucose]
GO:0010628 [positive regulation of gene expression]
GO:0014003 [oligodendrocyte development]
GO:0014070 [response to organic cyclic compound]
GO:0021522 [spinal cord motor neuron differentiation]
GO:0021529 [spinal cord oligodendrocyte cell differentiation]
GO:0021530 [spinal cord oligodendrocyte cell fate specification]
GO:0021554 [optic nerve development]
GO:0030154 [cell differentiation]
GO:0031018 [endocrine pancreas development]
GO:0032570 [response to progesterone]
GO:0043565 [sequence-specific DNA binding]
GO:0045595 [regulation of cell differentiation]
GO:0045597 [positive regulation of cell differentiation]
GO:0045665 [negative regulation of neuron differentiation]
GO:0045666 [positive regulation of neuron differentiation]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048468 [cell development]
GO:0048565 [digestive tract development]
GO:0048665 [neuron fate specification]
GO:0048708 [astrocyte differentiation]
GO:0048714 [positive regulation of oligodendrocyte differentiation]
GO:0051091 [positive regulation of sequence-specific DNA binding transcription factor activity]
GO:0060580 [ventral spinal cord interneuron fate determination]
Show all
 273 aa
30.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.