Expression of RBCK1 in cancer - Summary

CANCER ATLAS

Gene description

RanBP-type and C3HC4-type zinc finger containing 1

Protein class

Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024185

GENE INFORMATION
Gene name	RBCK1 (HGNC Symbol)
Synonyms	C20orf18, HOIL1, RBCK2, RNF54, UBCE7IP3, XAP4, ZRANB4
Description	RanBP-type and C3HC4-type zinc finger containing 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	407498 - 430966
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125826 (version 83.38)
Entrez gene	10616
UniProt	Q9BYM8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BYM8
Antibodypedia	RBCK1 antibodies

PROTEIN BROWSER

RBCK1-001	RBCK1-002	RBCK1-004	RBCK1-006	RBCK1-007	RBCK1-009	RBCK1-010	RBCK1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RBCK1-001 ENSP00000417173 ENST00000475269	A6PVJ6 [Direct mapping] RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11.8 kDa	No	0
RBCK1-002 ENSP00000383106 ENST00000400247	A6PVJ5 [Direct mapping] RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		63 aa 7.1 kDa	No	0
RBCK1-004 ENSP00000415080 ENST00000411647	Q5JWR1 [Direct mapping] RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		117 aa 13.3 kDa	No	0
RBCK1-006 ENSP00000371616 ENST00000382181	A6PVK0 [Direct mapping] HCG2019817, isoform CRA_b; RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		340 aa 37.4 kDa	No	0
RBCK1-007 ENSP00000393841 ENST00000414880	H0Y4S7 [Direct mapping] RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	255 aa 28.3 kDa	No	0
RBCK1-009 ENSP00000254960 ENST00000353660	Q9BYM8 [Direct mapping] RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0004842 [ubiquitin-protein transferase activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016874 [ligase activity] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0071797 [LUBAC complex] GO:0097039 [protein linear polyubiquitination] Show all	468 aa 52.9 kDa	No	0
RBCK1-010 ENSP00000348632 ENST00000356286	Q9BYM8 [Direct mapping] RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Plasma proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000209 [protein polyubiquitination] GO:0003690 [double-stranded DNA binding] GO:0004842 [ubiquitin-protein transferase activity] GO:0005080 [protein kinase C binding] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007166 [cell surface receptor signaling pathway] GO:0007249 [I-kappaB kinase/NF-kappaB signaling] GO:0008270 [zinc ion binding] GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway] GO:0016032 [viral process] GO:0016874 [ligase activity] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042346 [positive regulation of NF-kappaB import into nucleus] GO:0043065 [positive regulation of apoptotic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043130 [ubiquitin binding] GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0050852 [T cell receptor signaling pathway] GO:0051092 [positive regulation of NF-kappaB transcription factor activity] GO:0060546 [negative regulation of necroptotic process] GO:0071797 [LUBAC complex] GO:0097039 [protein linear polyubiquitination] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	510 aa 57.6 kDa	No	0
RBCK1-013 ENSP00000387799 ENST00000441733	A6PVJ7 [Direct mapping] RanBP-type and C3HC4-type zinc finger-containing protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	117 aa 13.3 kDa	No	0