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RBCK1

GENERAL INFORMATION

Gene name

 RBCK1

Gene description

 RanBP-type and C3HC4-type zinc finger containing 1

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA024185
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 RBCK1 (HGNC Symbol)

Synonyms

 C20orf18, HOIL1, RBCK2, RNF54, UBCE7IP3, XAP4, ZRANB4

Description

 RanBP-type and C3HC4-type zinc finger containing 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is similar to mouse UIP28/UbcM4 interacting protein. Alternative splicing has been observed at this locus, resulting in distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 407498 - 430966

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125826 (version 83.38)

Entrez gene

 10616

UniProt

 Q9BYM8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BYM8

Antibodypedia

 RBCK1 antibodies

PROTEIN BROWSER
RBCK1-001
RBCK1-002
RBCK1-004
RBCK1-006
RBCK1-007
RBCK1-009
RBCK1-010
RBCK1-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RBCK1-001
ENSP00000417173
ENST00000475269
A6PVJ6 [Direct mapping]
RanBP-type and C3HC4-type zinc finger-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 105 aa
11.8 kDa 		No 0
RBCK1-002
ENSP00000383106
ENST00000400247
A6PVJ5 [Direct mapping]
RanBP-type and C3HC4-type zinc finger-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 63 aa
7.1 kDa 		No 0
RBCK1-004
ENSP00000415080
ENST00000411647
Q5JWR1 [Direct mapping]
RanBP-type and C3HC4-type zinc finger-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 117 aa
13.3 kDa 		No 0
RBCK1-006
ENSP00000371616
ENST00000382181
A6PVK0 [Direct mapping]
HCG2019817, isoform CRA_b; RanBP-type and C3HC4-type zinc finger-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 340 aa
37.4 kDa 		No 0
RBCK1-007
ENSP00000393841
ENST00000414880
H0Y4S7 [Direct mapping]
RanBP-type and C3HC4-type zinc finger-containing protein 1
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   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0008270 [zinc ion binding]
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 255 aa
28.3 kDa 		No 0
RBCK1-009
ENSP00000254960
ENST00000353660
Q9BYM8 [Direct mapping]
RanBP-type and C3HC4-type zinc finger-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0071797 [LUBAC complex]
GO:0097039 [protein linear polyubiquitination]
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 468 aa
52.9 kDa 		No 0
RBCK1-010
ENSP00000348632
ENST00000356286
Q9BYM8 [Direct mapping]
RanBP-type and C3HC4-type zinc finger-containing protein 1
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000209 [protein polyubiquitination]
GO:0003690 [double-stranded DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005080 [protein kinase C binding]
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0008270 [zinc ion binding]
GO:0010803 [regulation of tumor necrosis factor-mediated signaling pathway]
GO:0016032 [viral process]
GO:0016874 [ligase activity]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0042346 [positive regulation of NF-kappaB import into nucleus]
GO:0043065 [positive regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043130 [ubiquitin binding]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050852 [T cell receptor signaling pathway]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0060546 [negative regulation of necroptotic process]
GO:0071797 [LUBAC complex]
GO:0097039 [protein linear polyubiquitination]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 510 aa
57.6 kDa 		No 0
RBCK1-013
ENSP00000387799
ENST00000441733
A6PVJ7 [Direct mapping]
RanBP-type and C3HC4-type zinc finger-containing protein 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 117 aa
13.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.