Expression of PROZ in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Protein Z, vitamin K-dependent plasma glycoprotein

Protein class

Candidate cardiovascular disease genes, Enzymes, Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA052006

GENE INFORMATION
Gene name	PROZ (HGNC Symbol)
Synonyms	PZ
Description	Protein Z, vitamin K-dependent plasma glycoprotein (HGNC Symbol)
Entrez gene summary	This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Chromosome	13
Cytoband	q34
Chromosome location (bp)	113158654 - 113172383
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126231 (version 83.38)
Entrez gene	8858
UniProt	P22891 (UniProt - Evidence at protein level)
neXtProt	NX_P22891
Antibodypedia	PROZ antibodies

PROTEIN BROWSER

PROZ-001	PROZ-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PROZ-001 ENSP00000364697 ENST00000375547	P22891 [Direct mapping] Vitamin K-dependent protein Z Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	400 aa 44.7 kDa	Yes	0
PROZ-002 ENSP00000344458 ENST00000342783	P22891 [Direct mapping] Vitamin K-dependent protein Z Show all	Enzymes Peptidases Serine-type peptidases SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0004252 [serine-type endopeptidase activity] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005788 [endoplasmic reticulum lumen] GO:0005796 [Golgi lumen] GO:0006508 [proteolysis] GO:0007596 [blood coagulation] GO:0017187 [peptidyl-glutamic acid carboxylation] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	422 aa 47.1 kDa	Yes	0