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Cytoplasmic expression at variable levels in several tissues, most abundant in liver.
DATA RELIABILITY
Data reliability description
Antibody staining mainly consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
RNA tissue category: Group enriched (liver, kidney)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (liver)
GENE INFORMATION
Gene name
PROZ (HGNC Symbol)
Synonyms
PZ
Description
Protein Z, vitamin K-dependent plasma glycoprotein (HGNC Symbol)
Entrez gene summary
This gene encodes a liver vitamin K-dependent glycoprotein that is synthesized in the liver and secreted into the plasma. The encoded protein plays a role in regulating blood coagulation by complexing with protein Z-dependent protease inhibitor to directly inhibit activated factor X at the phospholipid surface. Deficiencies in this protein are associated with an increased risk of ischemic arterial diseases and fetal loss. Mutations in this gene are the cause of protein Z deficiency. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]