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Most cancer tissues displayed moderate granular cytoplasmic immunoreactivity. Gliomas, lymphomas, colorectal and testicular cancers showed strong cytoplasmic staining. Most renal carcinomas were weakly stained or negative.
GENE INFORMATION
Gene name
IRF3
Synonyms
Description
Interferon regulatory factor 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000975 [regulatory region DNA binding] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0009617 [response to bacterium] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0031663 [lipopolysaccharide-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032496 [response to lipopolysaccharide] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043330 [response to exogenous dsRNA] GO:0045087 [innate immune response] GO:0045351 [type I interferon biosynthetic process] GO:0050715 [positive regulation of cytokine secretion] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway] GO:0071222 [cellular response to lipopolysaccharide] GO:0071359 [cellular response to dsRNA] GO:0071888 [macrophage apoptotic process] GO:0097300 [programmed necrotic cell death]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0002224 [toll-like receptor signaling pathway] GO:0002756 [MyD88-independent toll-like receptor signaling pathway] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003712 [transcription cofactor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0006974 [cellular response to DNA damage stimulus] GO:0016032 [viral process] GO:0019221 [cytokine-mediated signaling pathway] GO:0032480 [negative regulation of type I interferon production] GO:0032481 [positive regulation of type I interferon production] GO:0032727 [positive regulation of interferon-alpha production] GO:0032728 [positive regulation of interferon-beta production] GO:0034138 [toll-like receptor 3 signaling pathway] GO:0034142 [toll-like receptor 4 signaling pathway] GO:0035666 [TRIF-dependent toll-like receptor signaling pathway] GO:0039530 [MDA-5 signaling pathway] GO:0042802 [identical protein binding] GO:0042803 [protein homodimerization activity] GO:0045087 [innate immune response] GO:0051607 [defense response to virus] GO:0060333 [interferon-gamma-mediated signaling pathway] GO:0060337 [type I interferon signaling pathway] GO:0071888 [macrophage apoptotic process]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0006355 [regulation of transcription, DNA-templated]
Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005737 [cytoplasm] GO:0006355 [regulation of transcription, DNA-templated]