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IRF3

GENERAL INFORMATION

Gene name

 IRF3

Gene description

 Interferon regulatory factor 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 22
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Low cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA004895 , CAB013018
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 IRF3

Synonyms

Description

 Interferon regulatory factor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Chromosome

 19

Cytoband

 q13.33

Chromosome location (bp)

 49659569 - 49665875

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126456 (version 83.38)

Entrez gene

 3661

UniProt

 Q14653 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14653

Antibodypedia

 IRF3 antibodies

PROTEIN BROWSER
«
IRF3-001
IRF3-002
IRF3-004
IRF3-005
IRF3-006
IRF3-007
IRF3-008
IRF3-009
IRF3-010
IRF3-011
IRF3-012
IRF3-017
IRF3-019
IRF3-020
IRF3-022
IRF3-023
IRF3-024
IRF3-025
IRF3-027
IRF3-028
IRF3-201
IRF3-202
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IRF3-001
ENSP00000366344
ENST00000377139
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071888 [macrophage apoptotic process]
Show all
 427 aa
47.2 kDa 		No 0
IRF3-002
ENSP00000471896
ENST00000601291
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000975 [regulatory region DNA binding]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001078 [transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0009617 [response to bacterium]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032496 [response to lipopolysaccharide]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043330 [response to exogenous dsRNA]
GO:0045087 [innate immune response]
GO:0045351 [type I interferon biosynthetic process]
GO:0050715 [positive regulation of cytokine secretion]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071359 [cellular response to dsRNA]
GO:0071888 [macrophage apoptotic process]
GO:0097300 [programmed necrotic cell death]
Show all
 452 aa
49.1 kDa 		No 0
IRF3-004
ENSP00000469113
ENST00000597198
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071888 [macrophage apoptotic process]
Show all
 427 aa
47.2 kDa 		No 0
IRF3-005
ENSP00000471358
ENST00000599223
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071888 [macrophage apoptotic process]
Show all
 300 aa
33.2 kDa 		No 0
IRF3-006
ENSP00000310127
ENST00000309877
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071888 [macrophage apoptotic process]
Show all
 427 aa
47.2 kDa 		No 0
IRF3-007
ENSP00000470431
ENST00000600911
M0QZB7 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 408 aa
44.5 kDa 		No 0
IRF3-008
ENSP00000470512
ENST00000596765
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071888 [macrophage apoptotic process]
Show all
 154 aa
16.7 kDa 		No 0
IRF3-009
ENSP00000470069
ENST00000599144
M0QYT9 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 281 aa
30.8 kDa 		No 0
IRF3-010
ENSP00000472582
ENST00000598808
M0QYT9 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 281 aa
30.8 kDa 		No 0
IRF3-011
ENSP00000472601
ENST00000593922
M0QYT9 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 281 aa
30.8 kDa 		No 0
IRF3-012
ENSP00000472700
ENST00000600022
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071888 [macrophage apoptotic process]
Show all
 154 aa
16.7 kDa 		No 0
IRF3-017
ENSP00000468911
ENST00000596822
M0QX56 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 135 aa
14 kDa 		No 0
IRF3-019
ENSP00000470140
ENST00000601809
M0QYX3 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 191 aa
21.1 kDa 		No 0
IRF3-020
ENSP00000470905
ENST00000600453
M0R007 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 102 aa
11.8 kDa 		No 0
IRF3-022
ENSP00000471517
ENST00000593818
M0R0X9 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 106 aa
11.5 kDa 		No 0
IRF3-023
ENSP00000469067
ENST00000595034
M0QXC8 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 119 aa
13 kDa 		No 0
IRF3-024
ENSP00000471402
ENST00000601373
M0R0R8 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 84 aa
9.2 kDa 		No 0
IRF3-025
ENSP00000473128
ENST00000596756
M0R3C2 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 264 aa
29.2 kDa 		No 0
IRF3-027
ENSP00000473176
ENST00000593337
M0R3E9 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 153 aa
17.4 kDa 		No 0
IRF3-028
ENSP00000472223
ENST00000598108
M0R205 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 287 aa
31.8 kDa 		No 0
IRF3-201
ENSP00000366339
ENST00000377135
M0QYT9 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0006355 [regulation of transcription, DNA-templated]
Show all
 281 aa
30.8 kDa 		No 0
IRF3-202
ENSP00000400378
ENST00000442265
Q14653 [Direct mapping]
Interferon regulatory factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000975 [regulatory region DNA binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003712 [transcription cofactor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0016032 [viral process]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0032480 [negative regulation of type I interferon production]
GO:0032481 [positive regulation of type I interferon production]
GO:0032727 [positive regulation of interferon-alpha production]
GO:0032728 [positive regulation of interferon-beta production]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0039530 [MDA-5 signaling pathway]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0071888 [macrophage apoptotic process]
Show all
 104 aa
12.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.